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Related Experiment Videos

Thin malignant melanomas with regression and metastases.

S G Ronan1, A M Eng, H A Briele

  • 1Department of Pathology, University of Illinois at Chicago 60612.

Archives of Dermatology
|October 1, 1987
PubMed
Summary

Partial regression in thin melanomas (≤0.76 mm) indicates a higher risk of metastasis. Extensive regression (≥75%) is linked to poorer outcomes, challenging the favorable prognosis for these skin cancer patients.

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Thin malignant melanomas (≤0.76 mm) are typically associated with a favorable prognosis.
  • Partial regression is a histological feature observed in some primary cutaneous melanomas.

Purpose of the Study:

  • To evaluate the prognostic significance of partial regression in thin malignant melanomas.
  • To determine if partial regression is associated with the development of metastases.

Main Methods:

  • Retrospective analysis of 575 patients with primary cutaneous melanoma.
  • Histologic evaluation for evidence and extent of partial regression in thin melanomas (≤0.76 mm).
  • Correlation of regression extent with metastasis development and patient survival.

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Main Results:

  • 18% of patients had thin melanomas; 29% of these showed partial regression.
  • Of patients with partial regression, 20% developed visceral metastases and died.
  • Extensive regression (≥75%) was observed in all fatal cases, while most survivors had <50% regression.
  • No metastasis occurred in thin melanomas without regression.

Conclusions:

  • Partial regression in thin melanomas does not guarantee a favorable prognosis.
  • Extensive partial regression (≥75%) in thin melanomas is a significant risk factor for metastasis.
  • Patients with significant partial regression in thin melanomas should not be classified as low-risk.