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[Renal Cell Carcinomas in Patients on Chronic Dialysis]
Tsuyoshi Matsuda1, Yasushi Mochizuki1, Yuta Mukae1
1The Department of Urology, Nagasaki University Graduate School of Biomedical Sciences.
Hinyokika Kiyo. Acta Urologica Japonica
|January 11, 2023
Summary
Patients with end-stage renal disease (ESRD) on dialysis have higher rates of renal cell carcinoma (RCC). Early detection of RCC in these patients is crucial for improving prognosis and survival outcomes.
Area of Science:
- Nephrology
- Oncology
- Urology
Context:
- Patients undergoing chronic dialysis for end-stage renal disease (ESRD) exhibit a higher incidence of renal cell carcinoma (RCC).
- Understanding the specific clinicopathological features and outcomes of RCC in this vulnerable population is essential for clinical management.
Purpose:
- To investigate the clinicopathological characteristics and survival outcomes of patients with ESRD who underwent nephrectomy for RCC.
- To identify factors associated with prognosis in dialysis patients diagnosed with RCC.
Summary:
- A study analyzed 54 ESRD patients who had nephrectomy for RCC between 1992 and 2019.
- Median follow-up was 5.1 years, with 5-year cancer-specific survival at 84.3% and overall survival at 61.8%.
- Symptomatic RCC, older age, longer dialysis duration, larger tumors, and higher stage were associated with worse outcomes.
Impact:
- Highlights the importance of early detection for improving the prognosis of renal cell carcinoma in patients with end-stage renal disease.
- Identifies older age and symptomatic presentation as independent predictors of poorer overall survival.
- Provides valuable data for oncologists and nephrologists managing RCC in dialysis patients.
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