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Abstract:
A case report of a renal (mixed) cell carcinoma found in a 35-year-old male with acquired renal polycystosis who had died from chronic renal insufficiency treated with chronic hemodialysis is presented. The morphogenesis and pathogenesis of acquired polycystic transformation of the kidneys in patients with chronic renal failure and the possible relation of the former to renal cell carcinoma are discussed. A preblastomogenic role is suggested for sclerotic changes arising in polycystic kidneys as well as for hepatitis B virus which may act as an oncogene.