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The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect

Xinyu Li1, Wei Huang2, Rongrong Tan1

  • 1Department of Psychiatry, The School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China; Department of Psychiatry, Brain Hospital of Hunan Province (The Second People's Hospital of Hunan Province), Changsha, Hunan, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 11, 2023
PubMed

Insights

Hesperidin, a natural compound, shows promise in preventing and treating central nervous system (CNS) diseases by reducing inflammation and cell death. Further clinical trials are needed to confirm its efficacy and safety in humans.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Central nervous system (CNS) disorders encompass neurodegenerative diseases, mental disorders, and neuroinflammation, posing significant health challenges.
  • Hesperidin, a natural flavanone glycoside, exhibits diverse biological activities with emerging evidence suggesting its potential in mitigating CNS diseases.

Purpose of the Study:

  • To review the neuropharmacological mechanisms underlying the preventive and therapeutic effects of hesperidin on CNS disorders.
  • To consolidate evidence from cellular, animal, and clinical studies regarding hesperidin's neuroprotective capabilities.

Main Methods:

  • Literature review of studies investigating hesperidin's effects on CNS diseases.
  • Analysis of data from cellular and animal models assessing neuropharmacological mechanisms.
  • Evaluation of existing clinical evidence for hesperidin's neuroprotective function.

Main Results:

  • Hesperidin demonstrates neuroprotective effects by inhibiting neuro-inflammatory and apoptotic pathways.
  • Preclinical studies indicate hesperidin can alleviate depression and enhance cognition and memory.
  • Clinical evidence supports hesperidin's neuroprotective role, though human data is limited.

Conclusions:

  • Hesperidin possesses significant potential as a therapeutic agent for various CNS disorders.
  • Further clinical trials are essential to validate hesperidin's efficacy and safety profile in human subjects.
  • Investigating hesperidin's role in managing depression and cognitive decline warrants further attention.

Keywords:
Anti-depressionCNS disordersHesperidinMental disorders

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