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HX and Me: Understanding Allostery, Folding, and Protein Machines

S Walter Englander1

  • 1Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA;

Annual Review of Biophysics
|January 11, 2023
PubMed
Summary

Protein hydrogen exchange (HX) research has advanced measurement, interpretation, and biophysical applications. This reflection covers early hemoglobin studies, the protein folding problem, and current protein machine investigations.

Keywords:
AAA+ proteinsautobiographyhemoglobin allosteryhydrogen exchangeprotein foldingprotein machines

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