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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Related Experiment Video

Updated: Aug 14, 2025

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Cold stored platelets - Increasing understanding and acceptance.

Richard R Gammon1, Jeffrey Hebert2, Kyungyoon Min3

  • 1OneBlood, 8669 Commodity Circle, Orlando, FL 32819, USA.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|January 11, 2023
PubMed
Summary
This summary is machine-generated.

Cold stored platelets (CSP) offer advantages over room temperature platelets (RTPs), including reduced contamination and waste. This review explores strategies to overcome challenges in CSP production and clinical implementation for improved patient care.

Keywords:
Cold stored plateletsRoom temperature plateletsTransfusion practiceTreatment efficacyTreatment indications

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Blood Banking

Background:

  • Platelet transfusions are crucial for managing thrombocytopenia and platelet dysfunction, reducing morbidity and mortality.
  • Current practice favors room temperature platelets (RTPs), but these have significant disadvantages.
  • Alternative methods like cold stored platelets (CSP) are being explored for improved efficacy and safety.

Purpose of the Study:

  • To review the rationale for producing and implementing cold stored platelets (CSP) in clinical settings.
  • To identify and propose strategies for overcoming challenges faced by blood centers (BCs) in CSP production.
  • To outline current indications and opportunities for healthcare providers to utilize CSP.

Main Methods:

  • Literature review focusing on CSP research, production, and clinical implementation.
  • Analysis of experiences from Consortium for Blood Availability members regarding CSP integration.
  • Examination of variance applications and clinical practice data for CSP utilization.

Main Results:

  • CSP demonstrate comparable hemostatic function and restoration of platelet dysfunction to RTPs.
  • CSP offer benefits such as reduced bacterial contamination and decreased wastage compared to RTPs.
  • Despite advantages, CSP production by BCs and hospital adoption remain low.

Conclusions:

  • CSP represent a viable alternative to RTPs with significant potential benefits for patient outcomes and resource management.
  • Overcoming implementation barriers in BCs and promoting hospital uptake are critical for widespread CSP adoption.
  • Further research and strategic planning are needed to optimize CSP utilization in transfusion medicine.