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Regulation of Expression at Multiple Steps01:23

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Orchestration of tissue shape changes and gene expression patterns in development.

Koichiro Uriu1, Luis G Morelli2

  • 1Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192 Japan.

Seminars in Cell & Developmental Biology
|January 11, 2023
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Summary
This summary is machine-generated.

Tissue shape changes drive morphogenesis by influencing gene expression. This review explores how mechanical forces and cell behaviors in vertebrate somitogenesis impact dynamic gene patterns during development.

Keywords:
Presomitic mesodermSegmentation clockSomiteZebrafish

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Area of Science:

  • Developmental biology
  • Biophysics
  • Systems biology

Background:

  • Morphogenesis involves complex tissue shape changes and dynamic gene expression.
  • Understanding these processes requires analyzing mechanical properties like tissue rigidity and cell behaviors.
  • Neighboring cell interactions and tissue shape alterations significantly impact gene expression patterns.

Purpose of the Study:

  • To review mechanisms of tissue elongation in vertebrate somitogenesis.
  • To explore the influence of tissue shape changes on dynamic gene expression patterns.
  • To highlight the role of theoretical approaches in understanding tissue morphogenesis.

Main Methods:

  • Review of recent studies on vertebrate somitogenesis.
  • Analysis of mechanical and biochemical properties driving tissue elongation.
  • Discussion of patterning mechanisms under cell mixing and dynamic gene expression waves.

Main Results:

  • Tissue elongation is driven by specific mechanical and biochemical properties.
  • Cell mixing, signaling gradient scaling, and rhythmic gene expression waves are influenced by tissue shape changes.
  • Theoretical models are crucial for linking tissue shape dynamics to developmental patterning.

Conclusions:

  • Tissue shape changes are integral to morphogenesis and influence dynamic gene expression.
  • Vertebrate somitogenesis provides a key model for studying these coupled processes.
  • Integrating mechanical, cellular, and genetic perspectives, aided by theoretical frameworks, is essential for advancing developmental biology.