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SUMO-specific protease 1 inhibitors-A literature and patent overview

Hang Li1,2, Leyuan Chen2, Yiliang Li2

  • 1College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Expert Opinion on Therapeutic Patents
|January 11, 2023
PubMed
Abstract

Insights

Targeting SUMO-specific protease 1 (SENP1), over-expressed in cancers, offers a new therapeutic strategy. Recent advances in SENP1 inhibitors show promise for novel anticancer drug development.

Area of Science:

  • Biochemistry
  • Oncology
  • Drug Discovery

Background:

  • SUMO-specific protease 1 (SENP1) is frequently over-expressed in various human cancers.
  • Targeting SENP1 presents a potential new strategy for cancer therapy.

Approach:

  • This review analyzes recent literature and patents (last 10 years) on SENP1 inhibitor development.
  • Searches were conducted using SENP1 as a keyword across PubMed, Google Scholar, and ScienceDirect databases.

Key Points:

  • Complex crystal structures of SENP1-SUMO1 enable structure-based drug design.
  • Development of diverse small molecule inhibitors, including benzamide and naphthalene sulfonic acid derivatives.
  • Isoform-selective inhibitors have been designed based on structural insights.

Conclusions:

  • Preclinical studies indicate the potential advantages of novel SENP1 inhibitors.
  • These findings hold significance for the advancement of anticancer drug development.
Keywords:
SENP1anticancerdrug discoveryinhibitors

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