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The Landscape of Single Nucleotide Polymorphisms in Papillary Thyroid Carcinoma
Efthymios Kyrodimos1, Aristeidis Chrysovergis1, Nicholas Mastronikolis2
1First ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
Abstract:
Thyroid carcinoma represents a leading malignancy among those derived from human endocrine systems. It comprises a variety of different histological subtypes, including mainly papillary carcinoma, follicular carcinoma, anaplastic carcinoma, and medullar carcinoma. A broad spectrum of genetic imbalances, comprising gross chromosomal (polysomy/aneuploidy) and specific gene (mutations, amplifications, deletions) alterations, has been reported. Interestingly, the role of isolated, specific gene polymorphisms, especially of the single nucleotide polymorphism (SNP) type, in thyroid carcinoma is under investigation. SNPs are the most common genetic variations in the genome. The current molecular review focuses on the impact of specific SNPs on the biological behavior of papillary thyroid carcinoma in their carriers.
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