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Updated: Aug 14, 2025

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Checkpoint inhibitor hepatotoxicity: pathogenesis and management.

Morven Cunningham1, Rohit Gupta1, Marcus Butler2

  • 1Toronto Centre for Liver Disease, University Health Network, Toronto, Ontario, Canada.

Hepatology (Baltimore, Md.)
|January 12, 2023
PubMed
Summary

Immune checkpoint inhibitor (ICI) therapy revolutionizes cancer treatment but can cause liver damage (hepatotoxicity). Management strategies are evolving beyond corticosteroids to address severe or atypical cases and their impact on cancer outcomes.

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