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Anxiety is associated with coronary microvascular dysfunction: Results from the CAMADA study
Ying Li1, Weixian Xu2, Lijun Guo2
1Department of Geriatrics, Peking University Third Hospital, Beijing, China.
Microcirculation (New York, N.Y. : 1994)
|January 12, 2023
Summary
Anxiety is linked to lower coronary microvascular function in patients with nonobstructive coronary artery disease. This suggests psychological disorders may impact heart health.
Area of Science:
- Cardiology
- Psychosomatic Medicine
- Diagnostic Imaging
Background:
- Coronary microvascular dysfunction (CMD) is a key factor in ischemic heart disease.
- Understanding the influence of psychological factors on CMD is crucial for comprehensive patient care.
Purpose of the Study:
- To investigate the association between anxiety and depression with coronary microvascular function.
- To identify if psychological distress is an independent predictor of CMD.
Main Methods:
- The study included 81 patients with nonobstructive coronary artery disease.
- Anxiety and depression symptoms were assessed using standardized self-rating scales.
- Coronary microvascular function was evaluated by measuring coronary flow reserve (CFR) via transthoracic Doppler echocardiography.
Main Results:
- Patients experiencing anxiety exhibited significantly lower CFR compared to those without anxiety (p = .029).
- Anxiety showed a significant negative correlation with CFR (r = -.333, p = .002).
- After adjusting for clinical confounders, anxiety remained independently associated with reduced CFR (β = -.314, p = .008).
Conclusions:
- Anxiety is independently associated with impaired coronary microvascular function.
- Psychological disorders, particularly anxiety, may play a significant role in the development or exacerbation of coronary microvascular dysfunction.
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