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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

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Mobile Game-based Virtual Reality Program for Upper Extremity Stroke Rehabilitation
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A Real-Time Mobile Intervention to Reduce Sedentary Behavior Before and After Cancer Surgery: Pilot Randomized

Carissa A Low1, Michaela Danko1, Krina C Durica1

  • 1University of Pittsburgh, Pittsburgh, PA, United States.

JMIR Perioperative Medicine
|January 12, 2023
PubMed
Summary

A mobile intervention to reduce sedentary behavior (SB) after cancer surgery was acceptable but not effective. Patient engagement decreased post-surgery, showing no benefits and potential harm in SB duration.

Keywords:
abdominal cancer surgeryactivity monitoringmobile healthmobile phoneperioperative cancer patientsperioperative interventionphysical activitysedentary behaviorsmartphonesurgical oncologysurgical recoverywearable device

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Area of Science:

  • Oncology
  • Digital Health
  • Behavioral Science

Background:

  • Sedentary behavior (SB) is common after abdominal cancer surgery, impacting recovery.
  • Perioperative interventions targeting SB may enhance postoperative outcomes.
  • A pilot study assessed a mobile intervention for real-time SB detection and disruption.

Purpose of the Study:

  • Evaluate the feasibility and preliminary effects of a perioperative SB intervention.
  • Assess impact on objective activity, quality of life, symptoms, and readmissions.
  • Examine patient engagement and intervention acceptability.

Main Methods:

  • 26 patients with metastatic gastrointestinal cancer were randomized to an SB intervention or monitoring-only group.
  • Fitbit smartwatches and apps collected activity data and patient-reported symptoms.
  • Intervention group received prompts to walk after prolonged SB bouts.

Main Results:

  • High accrual (74%) and retention (88%) with good acceptability (88.5/100 satisfaction).
  • Engagement with the intervention and assessments significantly decreased post-surgery.
  • No significant benefits observed; intervention group showed longer maximum SB bouts.

Conclusions:

  • Patients were interested in the SB intervention, rating it highly acceptable.
  • Post-surgery engagement decline limited feasibility and benefits.
  • Further modifications are needed to improve mobile health technology engagement and effectiveness in cancer patients.