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  3. Regulating Eef2 And Eef2k In Skeletal Muscle By Exercise.
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  3. Regulating Eef2 And Eef2k In Skeletal Muscle By Exercise.

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Regulating eEF2 and eEF2K in skeletal muscle by exercise.

Kia Salimi1, Masoomeh Alvandi2, Mahdi Saberi Pirouz3

  • 1Department of Exercise Physiology, Faculty of Sport and Exercise Sciences, University of Tehran, Tehran, Iran.

Archives of Physiology and Biochemistry
|January 12, 2023

View abstract on PubMed

Summary
This summary is machine-generated.

Exercise training impacts skeletal muscle's translation elongation pathway, a key step in muscle protein synthesis (MPS). This review explores molecular factors and exercise types influencing this crucial pathway for muscle adaptation.

Keywords:
Skeletal muscleelongation pathwayexercise training

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Area of Science:

  • Exercise Physiology
  • Molecular Biology
  • Skeletal Muscle Biology

Background:

  • Skeletal muscle adapts to exercise by increasing muscle protein synthesis (MPS).
  • Translation elongation is a critical, yet understudied, rate-limiting step in MPS.
  • Elongation factors are regulated by cellular energy status and physiological stimuli like exercise.

Purpose of the Study:

  • To review the effects of exercise training on the skeletal muscle translation elongation pathway.
  • To elucidate the molecular factors regulating translation elongation in response to exercise.
  • To discuss the influence of exercise mode and volume on this pathway.

Main Methods:

  • Literature review focusing on molecular mechanisms and signaling pathways.
  • Analysis of experimental data on translation elongation during and after exercise.
  • Synthesis of current understanding regarding exercise and MPS regulation.

    • Main Results:

    • Exercise training influences the translation elongation pathway through various signaling cascades.
    • Key molecular factors including Ca2+, AMPK, PKA, mTORC1/P70S6K, MAPKs, and myostatin are implicated.
    • Exercise modulates the regulation of translation elongation, impacting overall MPS.

    Conclusions:

    • Exercise training plays a significant role in modulating the translation elongation pathway in skeletal muscle.
    • A deeper understanding of these mechanisms enhances knowledge of exercise-induced muscle adaptation.
    • Further research into translation elongation offers insights into optimizing MPS through exercise interventions.