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Updated: Aug 14, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

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The role of adiponectin in cardiovascular disease

Jin Peng1, Qian Chen1, Chuncao Wu2

  • 1Clinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|January 12, 2023
PubMed

Insights

Adiponectin, a hormone released by fat cells, shows promise in treating cardiovascular diseases (CVD). Further research into adiponectin may lead to new therapeutic targets for CVD.

Area of Science:

  • Endocrinology
  • Cardiology
  • Molecular Biology

Background:

  • Cardiovascular disease (CVD) poses a significant global health threat, particularly to individuals over 50.
  • Adiponectin, a key adipokine, is increasingly recognized for its protective roles in cardiovascular health.
  • Existing research suggests adiponectin possesses therapeutic potential against various CVDs.

Purpose of the Study:

  • To review the structure and function of adiponectin and its receptors.
  • To elucidate the mechanisms by which adiponectin protects against cardiovascular disease.
  • To analyze the clinical significance and therapeutic potential of adiponectin in CVD.

Main Methods:

  • Literature review focusing on adiponectin's role in cardiovascular health.
  • Analysis of molecular and cellular mechanisms of adiponectin action.
  • Evaluation of clinical studies and potential applications of adiponectin.

Main Results:

  • Adiponectin improves lipid metabolism and protects vascular endothelial cells.
  • It inhibits foam cell formation and vascular smooth muscle cell proliferation.
  • Adiponectin demonstrates protective effects across a spectrum of cardiovascular conditions.

Conclusions:

  • Adiponectin plays a crucial role in cardiovascular protection.
  • Understanding the adiponectin system offers novel therapeutic strategies for CVD.
  • Adiponectin is a potential therapeutic target and biomarker for CVD diagnosis and treatment.

Keywords:
AdiponectinCardiovascular diseaseTherapeutic strategy

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