Related Experiment Video

Updated: Aug 14, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.6K

Psychosomatic Aspects of The Development of Comorbid Pathology: A Review

Roza Tatayeva1, Ekaterina Ossadchaya1, Saule Sarculova2

  • 1Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan.

Medical Journal of the Islamic Republic of Iran
|January 13, 2023
PubMed

Insights

Comorbid anxiety-depressive disorders and physical illness worsen disease severity and complicate diagnosis. This review highlights the bidirectional link between mental and somatic health, emphasizing the need for further clinical trials.

Area of Science:

  • Psychiatry
  • Internal Medicine
  • Public Health

Background:

  • Reviews literature on somatic and mental pathologies with shared pathophysiological, genetic, and neurochemical mechanisms.
  • Examines psychosomatic manifestations in cardiovascular diseases and COVID-19.
  • Focuses on post-traumatic stress disorder in war participants.

Purpose of the Study:

  • To review literature on comorbid psychiatric and somatic disorders.
  • To explore the impact of combined mental and physical illnesses on disease course and diagnosis.
  • To identify research gaps in understanding these complex interactions.

Main Methods:

  • Literature search conducted in PubMed, Mendeley, Google Scholar, and ScienceDirect.
  • Included studies published between 2012 and 2022.
  • Focused on identifying associations between psychiatric and somatic pathologies.

Main Results:

  • Revealed a bidirectional association between comorbid psychiatric and somatic disorders.
  • Somatic disease prevalence increases with a predominance of mental disorders.
  • Anxiety-depressive disorders combined with physical illness worsen disease severity.

Conclusions:

  • Growing evidence links anxiety-depressive disorders and physical illness, worsening disease prognosis.
  • Combined conditions complicate the diagnosis of physical symptoms.
  • Further clinical trials are necessary to elucidate the full mechanisms of action.

Keywords:
AnxietyCOVID-19Comorbid PathologyDepressionPost-traumatic Stress Disorder (PTSD)Cardiovascular Disease (CVD)Stress

More Related Videos

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

12.6K
Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

430

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
831
Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
271
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
152
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
65
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
159
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
114