Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatosensation01:33

Somatosensation

37.0K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
37.0K
Muscles of the Leg that Move the Foot and Toes01:28

Muscles of the Leg that Move the Foot and Toes

1.9K
The human leg comprises an intricate system of muscles that facilitate the movement of feet and toes. Within this system, the muscles are categorized into the anterior, lateral, and posterior compartments, each with a unique set of muscles carrying out specific functions.
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles....
1.9K
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

5.3K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immersive virtual reality with synchronous neurostimulation for upper-limb recovery after stroke: a randomized feasibility trial.

Nature medicine·2026
Same author

Merging neural stimulation and exoskeletons to enhance sensorimotor hand functions after brain or spinal cord injury.

Science advances·2026
Same author

Technologies in clinical neurophysiology for brain-body interfacing: IFCN handbook chapter.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Sensory and cortical biomarkers unveil pain modulation mechanisms induced by targeted multisensory neurostimulation.

Journal of neuroengineering and rehabilitation·2026
Same author

Neuroprosthetics: between embodiment and restoration.

The Lancet. Neurology·2026
Same author

Decoding phantom limb movements from intraneural recordings.

Nature communications·2026

Related Experiment Video

Updated: Aug 14, 2025

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

10.9K

Modeling foot sole cutaneous afferents: FootSim.

Natalija Katic1,2,3, Rodrigo Kazu Siqueira4, Luke Cleland4

  • 1School of Electrical Engineering, University of Belgrade, 11 000 Belgrade, Serbia.

Iscience
|January 13, 2023
PubMed
Summary

We created FootSim, a computational model simulating foot sole mechanoreceptor activity during movement. This tool aids neuroscience research and develops better neuroprosthetics by analyzing tactile feedback.

Keywords:
Biocomputational methodSystems neurosciencesensory neuroscience

More Related Videos

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
10:28

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

1.3K
Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

2.8K

Related Experiment Videos

Last Updated: Aug 14, 2025

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

10.9K
Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
10:28

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

1.3K
Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

2.8K

Area of Science:

  • Neuroscience
  • Biomechanics
  • Computational Modeling

Background:

  • Human balance and locomotion depend on cutaneous feedback from the foot sole.
  • Current electrophysiological recordings of tactile feedback are limited to stationary conditions and difficult to obtain.

Purpose of the Study:

  • To develop a realistic computational model, FootSim, replicating mechanoreceptor activation in the foot sole.
  • To simulate neural spiking responses to diverse mechanical stimuli in dynamic conditions.
  • To provide an in silico tool for neuroscientific research and neuroprosthetic development.

Main Methods:

  • Developed the FootSim model incorporating foot sole skin mechanics and four types of mechanoreceptors.
  • Simulated neural spiking responses to arbitrary mechanical stimuli.
  • Calibrated model parameters using human microneurography data.

Main Results:

  • FootSim realistically replicates mechanoreceptor activation and neural spiking in the foot sole.
  • The model accounts for the specific mechanical properties of foot sole skin tissue.
  • Model parameters were successfully fitted using existing human microneurography datasets.

Conclusions:

  • FootSim offers a powerful in silico tool for studying afferent neural activation during dynamic activities.
  • The model overcomes limitations of current experimental recording techniques for tactile feedback research.
  • FootSim can advance neuroprosthetic design and biomimetic stimulation pattern development.