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Alexandra Golembiovska Frydkjær1, Frederik de Fine Olivarius2, Michael Prangsgaard Møller1

  • 1Afdeling for Plastikkirurgi, Herlev Hospital.

Ugeskrift for Laeger
|January 13, 2023
PubMed
Summary
This summary is machine-generated.

New vitiligo onset, particularly in older individuals with a melanoma history, may indicate undiagnosed melanoma. Early detection is crucial for patients presenting with these symptoms.

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Area of Science:

  • Dermatology
  • Oncology
  • Autoimmune Diseases

Background:

  • Vitiligo is an autoimmune skin condition causing depigmentation.
  • A known association exists between vitiligo-like depigmentation and melanoma.
  • Late-onset vitiligo requires careful evaluation, especially in patients with prior melanoma.

Observation:

  • A case report details a 67-year-old male with late-onset vitiligo and a history of melanoma.
  • The patient was diagnosed with disseminated malignant melanoma 3.5 years after vitiligo onset.
  • This case highlights a potential link between vitiligo and melanoma in specific patient groups.

Findings:

  • The study emphasizes that new-onset vitiligo can be a sign of underlying melanoma.
  • Older patients and those with a history of melanoma are at higher risk.

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  • Vitiligo-like skin changes may mask or coincide with primary or recurrent melanoma.

    • Implications:

    • Increased awareness is needed among clinicians regarding the association of vitiligo and melanoma.
    • Prompt dermatological and oncological assessment is recommended for patients with late-onset vitiligo and melanoma history.
    • This case underscores the importance of vigilant follow-up for melanoma survivors presenting with depigmentation.