Vitiligo is an autoimmune disease of the skin characterized by melanocyte loss resulting in white patches, but there is also a well-known association of vitiligo-like depigmentation and melanoma. This is a case report of a 67-year-old male with late onset of vitiligo, with a history of melanoma, who was referred to a plastic surgery department 3,5 years after the onset of vitiligo and was now diagnosed with disseminated malignant melanoma. The aim of this study is to raise awareness that onset of vitiligo, especially in patients with higher age and previously melanoma history, could represent undiagnosed primary or recurrent melanoma.