Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Overview of Exosomes01:36

Overview of Exosomes

2.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tissue derived extracellular vesicles advance from disease mechanisms to clinical application.

Discover nano·2026
Same authorSame journal

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Diabetic β-Cell Apoptosis and Dedifferentiation by Delivering miR-4436.

Tissue engineering and regenerative medicine·2026
Same author

Nanomaterial-Based Approaches for the Isolation and Characterization of Extracellular Vesicles.

Analytical chemistry·2026
Same author

Small Extracellular Vesicles-Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Asymmetric Fe-Te Pairs Enhance Peroxymonosulfate Activation via Surface-Bound Hydroxyl Radicals Pathways.

Angewandte Chemie (International ed. in English)·2026
Same author

Dual-targeted engineered mesenchymal stem cell-derived extracellular vesicles delivering Nedd4 attenuate renal fibrosis in diabetic kidney disease.

Materials today. Bio·2026

Related Experiment Video

Updated: Aug 14, 2025

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

806

Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy.

Yuntong Sun1, Fengtian Sun1, Wenrong Xu1

  • 1Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China.

Tissue Engineering and Regenerative Medicine
|January 13, 2023
PubMed
Summary

Engineered extracellular vesicles (EVs) offer a promising cell-free therapy for tissue regeneration and targeted drug delivery. This review explores their properties, engineering strategies, and clinical potential in precision medicine.

Keywords:
EngineeringExtracellular vesiclesTargeted delivery

More Related Videos

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

392
Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.3K

Related Experiment Videos

Last Updated: Aug 14, 2025

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

806
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

392
Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.3K

Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Nanomedicine

Background:

  • Extracellular vesicles (EVs) are crucial for intercellular communication and protect cargo from degradation.
  • EVs show therapeutic potential in tissue regeneration and as drug delivery vehicles.
  • Modifying EVs enhances their efficacy and specificity for disease treatment.

Purpose of the Study:

  • To review the unique properties of EVs, including biogenesis, contents, and functions.
  • To summarize recent advances in engineered EVs construction strategies.
  • To discuss the applications of engineered EVs in targeted therapy and clinical translation.

Main Methods:

  • Literature review of EV properties and engineering strategies.
  • Analysis of engineered EVs for targeted cancer therapy.
  • Evaluation of engineered EVs for damaged tissue repair.

Main Results:

  • EVs possess unique properties making them ideal for therapeutic applications.
  • Various strategies exist for engineering EVs to improve targeting and efficacy.
  • Engineered EVs demonstrate potential in treating cancer and damaged tissues.

Conclusions:

  • Engineered EVs represent a next-generation platform for precision therapy.
  • Further research is needed to overcome challenges in clinical translation.
  • EV-based therapies hold significant promise for future medical applications.