Related Experiment Video
Updated: Aug 14, 2025

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo
Published on: June 29, 2022
The Use of Acellular Human Dermis as a Dorsal Camouflaging Graft in Rhinoplasty
C Claire Melancon1,2, Sai Challapalli1, Russell W H Kridel1,2
1Department of Otorhinolaryngology-Head and Neck Surgery, McGovern Medical School, Houston, Texas, USA.
Abstract:
Background: Acellular human dermis (AHD) has many uses in rhinoplasty, but its long-term use as a camouflaging graft has not been adequately described. Objective: To measure the long-term outcomes (infections/contour irregularities) of AHD used as a camouflage graft in rhinoplasty. Methods: A retrospective study of 91 patients who underwent rhinoplasty requiring AHD as a camouflage graft for a 20-year time period (2000-2020) was performed. Complications, revisions, and long-term outcomes were assessed. Surgical technique for AHD use as a dorsal and tip camouflage graft was described in detail and illustrated using intraoperative photography. Results: Of the 91 patients who required AHD in their rhinoplasties, 70 (77%) were performed in revision cases to thicken thinned and scarred skin envelopes. Only 1% had postoperative contour problems that were attributable to AHD, and only 3% had resorption of the AHD. Four percent had postoperative infections, all of which resolved with a single course of oral antibiotics. Patients were followed a mean of 3.8 years. Conclusions: AHD can be a safe, effective, and readily available option for use in thickening the nasal skin envelope in rhinoplasty.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
Reticular Dermis
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

