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Acute Retinal Necrosis: A Covid-19 Perspective.
Anitha Manoharan1, Aniruddha Agarwal2,3,4, Parthopratim Dutta Majumder5
1Department of Uvea, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, India.
Ocular Immunology and Inflammation
|January 13, 2023
Summary
Acute retinal necrosis (ARN) is a rare but severe cause of uveitis. This review examines nine cases of ARN linked to SARS-CoV-2 infection or COVID-19 vaccination, suggesting a potential association.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Immunology
Background:
- Acute retinal necrosis (ARN) is an uncommon but severe form of infectious retinitis.
- ARN can lead to significant vision loss and is a sight-threatening condition.
- The potential link between ARN and viral infections, including SARS-CoV-2, warrants investigation.
Purpose of the Study:
- To analyze reported cases of ARN following SARS-CoV-2 infection.
- To investigate ARN cases associated with anti-SARS-CoV-2 vaccinations.
- To evaluate the potential causal relationship between ARN and SARS-CoV-2 or its vaccine.
Main Methods:
- Systematic literature review of ARN cases.
- Analysis of patient data including medical history, symptoms, and outcomes.
- Correlation of ARN onset with SARS-CoV-2 infection or vaccination status.
Main Results:
- Nine cases of ARN were identified in the literature.
- Four cases were associated with SARS-CoV-2 infection.
- Five cases occurred in patients with a recent history of COVID-19 vaccination.
Conclusions:
- ARN has been reported following both SARS-CoV-2 infection and vaccination.
- A potential cause-to-effect relationship between ARN and SARS-CoV-2/vaccination is suggested.
- Further research is needed to confirm causality and understand the underlying mechanisms.
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