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Updated: Aug 14, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in

Bálint Rehó1, Lina Fadel1, Peter Brazda2

  • 1Department of Biophysics and Cell Biology, Faculty of Medicine, Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, Hungary.

The Journal of Biological Chemistry
|January 13, 2023
PubMed
Summary

Nuclear receptors (NRs) like retinoic acid receptor (RAR) and vitamin D receptor (VDR) compete for DNA binding sites. This competition, influenced by ligands and retinoid X receptor (RXR), impacts NR therapies.

Keywords:
DNA bindingFCSFRETRARRXRVDRcompetitionfluorescence correlation spectroscopynuclear receptors

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