Related Experiment Video

Updated: Aug 14, 2025

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

6.5K

Does financial hardship associate with abnormal quantitative myocardial perfusion and major adverse cardiovascular

Danai Kitkungvan1,2, Nils P Johnson1,2, Linh Bui1,2

  • 1Division of Cardiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|January 13, 2023
PubMed

Insights

Financial hardship in patients undergoing cardiac PET scans is linked to abnormal heart imaging and major adverse cardiovascular events (MACE). This association suggests financial strain impacts heart health beyond traditional risk factors, necessitating targeted interventions.

Area of Science:

  • Cardiology
  • Health Economics
  • Public Health

Background:

  • Limited data exist on the impact of financial hardship on coronary artery disease (CAD).
  • Understanding this relationship is crucial for comprehensive patient care and risk stratification.

Purpose of the Study:

  • To investigate the association between financial hardship and outcomes in patients referred for cardiac positron emission tomography (PET).
  • To determine if financial hardship independently predicts abnormal cardiac PET findings and major adverse cardiovascular events (MACE).

Main Methods:

  • A cohort of 4173 patients undergoing clinical rest/stress cardiac PET was analyzed.
  • Financial hardship was defined as inability to pay out-of-pocket expenses for the PET scan.
  • Outcomes included abnormal cardiac PET (perfusion defects or reduced coronary flow reserve) and MACE (mortality, myocardial infarction, revascularization).

Main Results:

  • 12.1% of patients (504) reported financial hardship.
  • Financial hardship was independently associated with abnormal cardiac PET (OR 1.377, p=0.004) and MACE (HR 1.432, p=0.010).
  • The association of financial hardship with MACE was primarily direct, with minimal mediation by abnormal PET or known CAD.

Conclusions:

  • Financial hardship is an independent predictor of myocardial perfusion abnormalities and MACE in patients referred for cardiac PET.
  • The impact of financial hardship on cardiovascular events extends beyond traditional risk factors and CAD severity.
  • Medical insurance does not fully mitigate financial hardship's impact; preventive strategies are needed.
Abstract

Keywords:
CADDiagnostic and prognostic applicationDiseases/processesModalitiesMyocardial blood flowOutcomesPETTests

More Related Videos

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

24.2K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.7K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
30
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.5K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.7K
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
36
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
473
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
37