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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

621
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Aug 14, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

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BATF reprograms the tumor immune status.

Tao Fan1, Chu Xiao1, Shan Muhammad1

  • 1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Med (New York, N.Y.)
|January 14, 2023
PubMed
Summary
This summary is machine-generated.

The AP-1 family member BATF protein is crucial for immune cell function. Recent studies show BATF depletion in CAR-T cells enhances anti-tumor activity and BATF promotes tumor immunosuppression via Tregs.

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Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • The Activator Protein 1 (AP-1) transcription factor family plays a role in immune cell regulation.
  • Basic leucine zipper transcription factor, ATF-associated চীনে (BATF) is an AP-1 family member essential for immune cell function.
  • Understanding BATF's role in cancer immunity is critical for developing novel cancer therapies.

Purpose of the Study:

  • To investigate the role of BATF in CAR-T cell-mediated anti-tumor immunity.
  • To elucidate BATF's contribution to the immunosuppressive tumor microenvironment, particularly through regulatory T cells (Tregs).

Main Methods:

  • Analysis of BATF's function in CAR-T cells.
  • Investigation of BATF's role in Treg-mediated immunosuppression within the tumor microenvironment.

Main Results:

  • Depletion of BATF in CAR-T cells was found to augment anti-tumor activity.
  • BATF was identified as a key contributor to Treg-mediated immunosuppression in the tumor microenvironment.

Conclusions:

  • BATF plays a dual role in cancer immunity, impacting both effector CAR-T cells and suppressive Tregs.
  • Targeting BATF could represent a promising strategy for enhancing cancer immunotherapy outcomes.