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Interferon and myeloproliferative neoplasms: Evolving therapeutic approaches

Alok Swaroop1,2, Diana Saleiro1,2, Leonidas C Platanias1,2,3

  • 1Division of Hematology and Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 16, 2023
PubMed

Interferons (IFNs) are a diverse group of cytokines whose potent antitumor effects have piqued the interest of scientists for decades. Some of the most sustained clinical accomplishments have been in the field of myeloproliferative neoplasms (MPNs). Here, we discuss how both historical and novel breakthroughs in our understanding of IFN function may lead to more effective therapies for MPNs. The particular relevance and importance of modulating the novel IFN-regulated ULK1 pathway to optimize IFN responses is highlighted.

Keywords:
JAK2cytokineessential thrombocytosisinterferonsmyeloproliferative neoplasmspolycythemia vera

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