Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Experimental study on topical antimicrobial agents in burns.

S D Ge¹, Z L Hu, Y L Cheng

¹Burn Center of Changhai Hospital, Second Military Medical College of PLA, Shanghai, PR China.

Burns, Including Thermal Injury

|August 1, 1987

Summary

Silver pipemidate demonstrated superior efficacy compared to silver sulfadiazine in treating Pseudomonas aeruginosa wound infections in animal models. This finding highlights its potential as a topical antimicrobial agent for wound care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Clinicopathological and molecular features of meningioma: an analysis of 134 cases based on high-throughput sequencing].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026

Same author

[Prediction of economic burden caused by thyroid cancer in China, 2025-2034].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026

Same author

[Analysis and prediction of periodontal disease burden among the elderly in China from 1990 to 2021].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2025

Same author

[CD117-positive eosinophilic renal cell tumors with uncertain classification: a clinicopathological and molecular genetic analysis of 10 cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2025

Same author

[Comparative study of clinicopathological features and prognosis of biliary tract cancer in different locations].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2025

Same author

[A cross-sectional survey of blindness and visual impairment among adults in 13 regions of China from 2021 to 2022].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2025

Area of Science:

Microbiology
Dermatology
Pharmacology

Background:

Pseudomonas aeruginosa is a common opportunistic pathogen causing severe wound infections.
Topical antimicrobial agents are crucial for managing burn and scald wounds.
Silver compounds have a long history of use in wound care due to their antimicrobial properties.

Purpose of the Study:

To evaluate the efficacy of various organic silver salts against Pseudomonas aeruginosa.
To compare the effectiveness of silver pipemidate and silver sulfadiazine in treating infected wounds.

Main Methods:

Infection of scald wounds in mice and rabbits with a virulent strain of Pseudomonas aeruginosa.
Topical application and assessment of different organic silver salts.
Comparative analysis of treatment outcomes between silver pipemidate and silver sulfadiazine.

Related Experiment Videos

Main Results:

Silver pipemidate exhibited greater effectiveness in treating Pseudomonas aeruginosa-infected scald wounds.
The efficacy of silver pipemidate surpassed that of silver sulfadiazine in the experimental models.
Both agents were tested against a virulent strain of Pseudomonas aeruginosa.

Conclusions:

Silver pipemidate represents a promising therapeutic option for Pseudomonas aeruginosa wound infections.
Further clinical investigations are warranted to confirm the efficacy of silver pipemidate in human wound treatment.
The study provides valuable data for the development of novel antimicrobial wound therapies.