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Updated: Jul 4, 2026

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
Published on: October 29, 2014
A rare case of neonatal meningoencephalitis from Paenibacillus thiaminolyticus
Laura S Smallcomb1, Terry C Dixon2, Kamran N Azad3
1PGY-4 Department of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC, SJCH, 10 McClennan Banks Dr. MSC 915. Charleston, SC 29425, USA.
Insights
This case report details a rare Paenibacillus thiaminolyticus meningoencephalitis in a US infant. The neonate survived this life-threatening infection after successful treatment with antibiotics.
Area of Science:
- Infectious Diseases
- Neurology
- Microbiology
Background:
- Paenibacillus infections are increasingly reported but rarely documented, often affecting immunocompromised individuals or those with medical devices.
- Improved diagnostics suggest Paenibacillus infections may be more common than previously thought.
Abstract:
Paenibacillus infections can be life threatening and are being reported with increasing incidence. There are only a few case reports of infections and are mainly described in patients who are immunocompromised, injection drug users, or those with prosthetic devices. Due to improved testing and identification, it appears that these infections may not be as rare as once perceived. We present a case of a 16-day-old term neonate who presented with status epilepticus and was found to have Paenibacillus thiaminolyticus meningoencephalitis. The patient was successfully treated with a combination of ampicillin and ceftazidime then meropenem. To our knowledge, this is the first reported case of an infant in the United States who survived this serious invasive infection. We also present an option for therapy given the difficulty treating invasive intracranial infections.
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