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Updated: Jul 27, 2026

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates
Published on: May 9, 2014
Layer-by-layer self-assembled emerging systems for nanosized drug delivery.
1Istanbul Technical University, Science and Letters Faculty, Chemistry Department, Maslak, Istanbul, 34469, Turkiye.
Stimuli-responsive surfaces using layer-by-layer (LbL) self-assembly create advanced nano-drug delivery systems (NDDS). This review highlights LbL-polyelectrolyte multilayers (PEMs) for novel drug loading and release strategies in NDDS.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Stimuli-responsive surfaces offer switchable properties for advanced applications.
- Layer-by-layer (LbL) self-assembly is a cost-effective strategy for nano-drug delivery systems (NDDS).
- Polyelectrolyte multilayers (PEMs) are versatile vehicles for NDDS.
Purpose of the Study:
- To provide a comprehensive overview of LbL-PEMs in NDDS.
- To focus on emerging drug loading and release strategies.
- To review advancements in the last five years.
Main Methods:
- Review of scientific literature on LbL self-assembly for NDDS.
- Analysis of studies utilizing LbL-based microcapsules and core-shell structures.
- Emphasis on polyelectrolyte multilayers (PEMs) as templates.
Main Results:
- LbL technologies enable versatile nano-drug delivery systems (NDDS).
- PEMs offer efficient encapsulation of diverse drug formulations.
- Emerging strategies focus on controlled drug loading and release.
Conclusions:
- LbL-PEMs are promising for next-generation drug delivery systems.
- Further research into stimuli-responsive properties can enhance NDDS.
- LbL assembly provides a scalable and adaptable platform for NDDS development.
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