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Genomic profiling and precision medicine in complex ameloblastoma.
James C Gates1, Allison P Clark2, Elliot Cherkas3
1Department of Oral and Maxillofacial Surgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, Pennsylvania, USA.
Head & Neck
|January 16, 2023
Summary
Comprehensive genomic profiling (CGP) helps identify targetable mutations in ameloblastoma. Targeted treatments show promise, with a majority of patients experiencing positive responses, offering new hope for complex cases.
Area of Science:
- Oncology
- Genomics
- Oral and Maxillofacial Surgery
Background:
- Ameloblastoma poses significant treatment challenges, particularly in advanced, recurrent, or metastatic stages.
- Identifying targetable genomic alterations is crucial for effective therapeutic strategies.
Conclusions:
- Comprehensive genomic profiling is effective in detecting specific driver mutations in complex ameloblastoma cases.
- Targeted therapies have demonstrated success in achieving treatment responses for ameloblastoma.
