Time to change the reference ranges of children's physiological observations in emergency care? A prospective study

Louise Brennan1,2, Calvin Heal3, Stephen Brown4

  • 1Lead Employer, St Helens and Knowsley Teaching Hospitals NHS Trust, St Helens, United Kingdom.

Insights

Current guidelines for pediatric sepsis may overestimate abnormal heart rates in children. This study suggests established normal heart rate ranges are too low, leading to unnecessary high-risk classifications.

Area of Science:

  • Pediatric Emergency Medicine
  • Clinical Physiology
  • Infectious Disease Diagnostics

Background:

  • High heart and respiratory rates are critical for identifying serious bacterial infections and sepsis in children.
  • The evidence supporting current 'abnormal' thresholds for these vital signs is questionable.
  • Accurate reference ranges are essential for timely and appropriate pediatric care.

Purpose of the Study:

  • To establish the distribution of heart and respiratory rates in children using a large dataset.
  • To compare pediatric vital sign distributions with Advanced Paediatric Life Support (APLS) guidelines.
  • To inform the debate on appropriate 'normal' ranges for pediatric heart and respiratory rates.

Main Methods:

  • Prospective study design.
  • Utilized anonymized patient data from electronic health records.
  • Included children aged 0-16 years from UK emergency and urgent care settings.

Main Results:

  • Children's heart and respiratory rates were consistently higher than APLS guidance thresholds.
  • A significant proportion of children exceeded 'severe' cut-off values, varying by age.
  • Respiratory rate distributions aligned more closely with existing guidelines and data.

Conclusions:

  • Current APLS and other normal heart rate ranges for children may be set too low.
  • Existing guidelines may classify too many children as having 'abnormal' measurements.
  • Respiratory rate guidelines appear more consistent with current data.
Abstract

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