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Time to change the reference ranges of children's physiological observations in emergency care? A prospective study
Louise Brennan1,2, Calvin Heal3, Stephen Brown4
1Lead Employer, St Helens and Knowsley Teaching Hospitals NHS Trust, St Helens, United Kingdom.
Insights
Current guidelines for pediatric sepsis may overestimate abnormal heart rates in children. This study suggests established normal heart rate ranges are too low, leading to unnecessary high-risk classifications.
Area of Science:
- Pediatric Emergency Medicine
- Clinical Physiology
- Infectious Disease Diagnostics
Background:
- High heart and respiratory rates are critical for identifying serious bacterial infections and sepsis in children.
- The evidence supporting current 'abnormal' thresholds for these vital signs is questionable.
- Accurate reference ranges are essential for timely and appropriate pediatric care.
Purpose of the Study:
- To establish the distribution of heart and respiratory rates in children using a large dataset.
- To compare pediatric vital sign distributions with Advanced Paediatric Life Support (APLS) guidelines.
- To inform the debate on appropriate 'normal' ranges for pediatric heart and respiratory rates.
Main Methods:
- Prospective study design.
- Utilized anonymized patient data from electronic health records.
- Included children aged 0-16 years from UK emergency and urgent care settings.
Main Results:
- Children's heart and respiratory rates were consistently higher than APLS guidance thresholds.
- A significant proportion of children exceeded 'severe' cut-off values, varying by age.
- Respiratory rate distributions aligned more closely with existing guidelines and data.
Conclusions:
- Current APLS and other normal heart rate ranges for children may be set too low.
- Existing guidelines may classify too many children as having 'abnormal' measurements.
- Respiratory rate guidelines appear more consistent with current data.
Aim:
High heart and respiratory rates are key indicators in many published guidelines to identify and treat serious bacterial infection and sepsis in children, but the credibility of evidence underpinning what is considered abnormal is questionable. This study established the distribution of heart and respiratory rates of children using a large data set to inform debate on what the 'normal' range of these should look like. The primary aim was to compare the distribution of heart and respiratory rates measured in children recruited from non-tertiary emergency care settings with those published by Advanced Paediatric Life Support (APLS). The secondary aim was to compare the distribution of this study's data set to other national guidance on what constitutes a severe (high-risk) measurement and previously published data sets.
Method:
Prospective study using anonymised patient data, extracted from electronic patient records of children and young people 0-16 years, recruited from three Emergency Departments and one Urgent Care Centre in Northwest England, UK.
Results:
Heart and respiratory rates, including the reporting of values at certain centiles and comparisons of averages. Distribution of heart and respiratory rate were consistently higher than those used by the APLS guidance, resulting in a large proportion exceeding the 'severe' cut-offs proposed. This varied greatly by age.
Conclusions:
This study's data set suggests normal heart rate ranges proposed by the APLS and others is too low and therefore 'abnormal' measurements encompass too large a proportion. The respiratory rate of this data set was more consistent with the guidelines and other published data sets.
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