Recurrent nephrolithiasis and loss of kidney function: a cohort study

Area of Science:

• Nephrology
• Urology
• Nephrolithiasis Research

Background:

• Nephrolithiasis, or kidney stones, is a common condition.
• Recurrent symptomatic episodes may impact kidney health.
• Understanding the long-term effects on kidney function is crucial.

Purpose of the Study:

• To determine if recurrent symptomatic nephrolithiasis causes a decline in kidney function.
• To identify factors associated with kidney function loss in these patients.

Main Methods:

• Retrospective study of adults with at least two symptomatic nephrolithiasis episodes.
• Primary endpoint: change in glomerular filtration rate (GFR) from baseline.
• Secondary endpoint: GFR slope over the follow-up period.

Main Results:

• 240 patients with recurrent symptomatic nephrolithiasis were analyzed.
• 17.5% experienced worsening GFR, averaging -8.64 ml/min/1.73 m² per year.
• Older age, more stone episodes, and non-calcium stones were linked to kidney function decline.

Conclusions:

• Recurrent symptomatic nephrolithiasis is associated with kidney function loss.
• Age is the sole significant predictor of worsening GFR, even after adjusting for comorbidities.
• This highlights the importance of managing recurrent kidney stones, especially in older populations.