Preparation and quality control of a new porphyrin complex labeled with ⁴⁵Ti for PET imaging

This study aims to produce and quality control of a new porphyrin complex labeled with ⁴⁵Ti for PET imaging, so at the first step, the cross-section of ⁴⁵Sc(p,n)⁴⁵Ti was investigated by TALYS-1.6 and the optimal target thickness and theoretical yield were calculated by SRIM code. The purified ⁴⁵Ti was labeled with the anticancer agent of tetrakis (pentafluorophenyl) porphyrin (TFPP). The radiochemical purity and the percentage of labeling were evaluated by radiation layer chromatography then the division coefficient of [⁴⁵Ti]-TFPP was calculated. The dual coincidence imaging system was used for imaging 1 and 2 h after injection [⁴⁵Ti]-TFPP to rats. Immediately after imaging, the mean percent injected dose per gram and specific activity of different tissues including blood, heart, lungs, stomach, liver, bone, kidney, spleen, intestine, muscle, feces, and skin were measured. The yield of ⁴⁵Ti production was measured 468 MBq/μAh and the labeling rate was observed more than 98%. The highest activity was observed in the liver (%ID/g = 2.27%, 1 h) and spleen (2.2%, 1 h), respectively, because of the high lipophilic of ⁴⁵Ti-TFPP. SPECT images showed a significant uptake of radiopharmaceuticals in the abdomen. The labeling rate of ⁴⁵Ti-TFPP was high and this compound has the potential for clinical application in different ways than PSMA, it can be joined with photodynamic therapy (Severin et al., 2015).