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Updated: Aug 14, 2025

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer
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A phosphorylation switch controls androgen biosynthesis in prostate cancer

Yun Qiu1,2

  • 1Departments of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

The Journal of Clinical Investigation
|January 17, 2023
PubMed
Summary

Prostate cancer patients with a specific HSD3B1 gene variant are resistant to AR-targeting drugs. Inhibiting BMX kinase blocks androgen production and tumor growth, offering a new therapeutic strategy.

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