Dysphagia Days as an Assessment of Clinical Treatment Outcome in Eosinophilic Esophagitis
Related Experiment Video
Updated: Aug 14, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Ikuo Hirano1, Marc E Rothenberg2,3, Sandra Zhang4
1Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Introduction:
The aim of this study was to evaluate Dysphagia Days as a measure of symptom improvement in patients with eosinophilic esophagitis from the HEROES study.
Methods:
Dysphagia Days, defined as a yes answer to the following question: During any meal today, did food go down slowly or get stuck in your throat or chest? was assessed for cendakimab vs placebo.
Results:
A statistically significant reduction in the mean number of Dysphagia Days experienced was observed with cendakimab 360 mg vs placebo at week 16 (-4.67 vs -1.83; P = 0.0115); an even greater improvement was observed in steroid-refractory patients vs placebo (-4.48 vs -0.04; P = 0.0079).
Discussion:
Dysphagia Days represents a relevant clinical end point to capture dysphagia-related symptoms.
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