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Published on: March 21, 2013
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Effect of Orthostatic Hypotension on Kidney Function
Jin Hee Na1, Sung Rok Kim1, Yu-Ji Lee1
1Division of Nephrology, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
Nephron
|January 17, 2023
Summary
Orthostatic hypotension (OH) is linked to faster kidney function decline. This study found OH patients experienced a greater decrease in estimated glomerular filtration rate (eGFR) over 12 years.
Area of Science:
- Nephrology
- Cardiology
- Epidemiology
Background:
- The relationship between orthostatic hypotension (OH) and long-term kidney function changes in the general population remains unclear.
- Orthostatic hypotension is a condition characterized by a significant drop in blood pressure upon standing.
Purpose of the Study:
- To investigate the association between classic orthostatic hypotension and longitudinal changes in kidney function.
- To assess the impact of OH on the decline of estimated glomerular filtration rate (eGFR) over a 12-year period.
Main Methods:
- A population-based cohort study utilizing data from the Korean Genome and Epidemiology Study (KoGES).
- Classic OH defined as a systolic blood pressure drop ≥20 mm Hg and/or diastolic blood pressure drop ≥10 mm Hg within 2 minutes of standing.
- Kidney function change measured by the difference in eGFR from baseline to 12-year follow-up.
Main Results:
- The study included 5,905 participants; 4.5% had classic OH.
- Participants with classic OH showed a significantly greater decline in eGFR over 12 years (beta = -1.74, 95% CI: -3.07 to -0.40).
- Classic OH was associated with a 27% increased risk of a 30% decline in kidney function (HR = 1.27, 95% CI: 1.07 to 1.49).
Conclusions:
- Classic orthostatic hypotension is associated with accelerated long-term decline in kidney function.
- Findings suggest OH is a risk factor for kidney function deterioration in the general population.
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