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Updated: Aug 14, 2025
Label-free Single Molecule Detection Using Microtoroid Optical Resonators
Published on: December 29, 2015
Degradable optical resonators as in situ microprobes for microscopy-based observation of enzymatic hydrolysis
Akihide Takeuchi1, Wey Yih Heah1, Yohei Yamamoto1
1Department of Materials Science, Institute of Pure and Applied Sciences, and Tsukuba Research Center for Energy Materials Science (TREMS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan. yamagishi.hiroshi.ff@u.tsukuba.ac.jp.
Abstract:
Optical resonators work as precise physical and chemical sensors. Here, we assemble a whispering gallery mode resonator from a natural polymer, fibroin protein, and successfully observe its catalytic degradation reaction as a spectral shift. This methodology will contribute to the precise in situ observation of biological reactions by optical microscopy.
