Progression of ECG in hydroxychloroquine overdose
Arushi Thaper1, Steven J Ross2, Zubin Agarwal2
1Department of Medicine, University of Florida, Gainesville, FL, United States of America.
Journal of Electrocardiology
|January 18, 2023
Summary
Hydroxychloroquine overdose can cause severe heart problems, including conduction delays and QT prolongation. This case highlights rapid cardiac abnormalities following an overdose, leading to bradycardia and shock.
Area of Science:
- Cardiology
- Clinical Toxicology
Background:
- Hydroxychloroquine (HCQ) overdose is a known cause of cardiotoxicity.
- Myocardial toxicity and conduction disorders are significant concerns in HCQ poisoning.
Observation:
- A case of significant hydroxychloroquine overdose is presented.
- The patient exhibited rapid progressive intraventricular conduction delay and QT prolongation.
Findings:
- The overdose resulted in severe bradycardia and shock.
- Sequential electrocardiograms captured the abrupt onset and progression of cardiac abnormalities.
Implications:
- This case underscores the critical need for prompt recognition and management of HCQ cardiotoxicity.
- Understanding the temporal evolution of ECG changes is vital for predicting and treating adverse outcomes.
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