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Illuminating the mechanism of IL-6-mediated immunotherapy resistance

Anna E Vilgelm1

  • 1Department of Pathology, The Ohio State University, Columbus, OH, USA; Wexner Medical Center, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, USA.

Cell Reports. Medicine
|January 18, 2023
PubMed

Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy.

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