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Related Experiment Video

Updated: Aug 14, 2025

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Scalable Printing of Bionic Multiscale Channel Networks Through Digital Light Processing-Based Three-Dimensional

Yue Wang1,2, Yancheng Wang1,3, Deqing Mei1,3

  • 1State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, China.

3D Printing and Additive Manufacturing
|January 19, 2023
PubMed
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A scalable 3D printing system using Digital Light Processing (DLP) enables high-precision fabrication of large, multiscale biomimetic channels. This advancement addresses key challenges in creating complex structures for biomedical applications.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • 3D Printing Technology

Background:

  • Digital Light Processing (DLP) 3D printing is utilized for microscale biomedical constructs.
  • A significant challenge remains in achieving both large printing dimensions and high accuracy simultaneously.
  • Existing DLP systems often face limitations in scalability for complex, multiscale applications.

Purpose of the Study:

  • To develop a scalable DLP-based 3D printing system capable of high-resolution fabrication.
  • To demonstrate the system's ability to print multiscale hydrogel fractal bionic channels with controllable resolution.
  • To address the challenge of simultaneously achieving large printing sizes and high precision in DLP 3D printing.

Main Methods:

  • Implemented a scalable DLP 3D printing system by incorporating movable convex lenses to adjust pixel size (6–12 μm).
Keywords:
3D printingcell culturingdigital light processing (DLP)fractal and bionic channelsmultiscale fabricationscalable

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  • Utilized poly (ethylene glycol) diacrylate (PEGDA) as the printing material.
  • Fabricated diverse multiscale architectures, including fractal Y-shaped channels and biomimetic capillary vascular networks.

    • Main Results:

    • Successfully printed regular fractal and intricate biomimetic channel networks with scalable resolution.
    • Demonstrated fluid filling of channels across a wide range of sizes (∼30 μm to >1500 μm) via capillarity.
    • Confirmed the biocompatibility of the printed multiscale channel networks through cell experiments.

    Conclusions:

    • The developed scalable DLP 3D printing system offers a significant advancement for fabricating large, high-precision multiscale constructs.
    • This technology holds promise for creating complex biomimetic structures for advanced biomedical applications.
    • The ability to control resolution and printing size opens new avenues for tissue engineering and regenerative medicine.