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Yoga: A Natural Solution to Decrease Disease Burden in Children of MTHFR Deficient Parents.

D Borthakur1, R Kumar2, R Dada1

  • 1Lab for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.

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|January 19, 2023
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Summary
This summary is machine-generated.

Yoga practice significantly up-regulates Methylenetetrahydrofolate reductase (MTHFR) gene expression and reduces seminal oxidative stress in infertile men. This intervention may help manage MTHFR deficiency consequences.

Keywords:
Folate-homocystine MetabolismMTHFRMTHFR PolymorphismOxidative stressYoga

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Area of Science:

  • Genetics and Molecular Biology
  • Metabolic Disorders
  • Reproductive Health

Background:

  • Methylenetetrahydrofolate reductase (MTHFR) is crucial for 1-carbon metabolism, SAM production, and DNA synthesis.
  • MTHFR gene mutations cause rare metabolic disorders, while common polymorphisms are linked to various diseases, including male infertility.
  • MTHFR gene polymorphisms are frequently observed and associated with increased susceptibility to neural tube defects, congenital heart disease, and neuropsychiatric disorders.

Purpose of the Study:

  • To investigate the potential of yoga practice to up-regulate MTHFR gene expression.
  • To assess the impact of yoga on MTHFR gene expression and seminal parameters in infertile men.
  • To explore the role of MTHFR gene variations in male infertility.

Main Methods:

  • A prospective clinical trial was conducted involving 30 infertile men.
  • Participants underwent a 3-week supervised yoga-based lifestyle intervention (YBLI).
  • Blood and semen samples were analyzed pre- and post-intervention to evaluate MTHFR gene expression and seminal oxidative stress markers.

Main Results:

  • Yoga practice resulted in a fivefold increase in MTHFR gene expression.
  • A significant reduction in seminal free radical levels was observed after 3 weeks of yoga.
  • Infertile males exhibited significantly higher MTHFR polymorphic variants compared to fertile controls.

Conclusions:

  • Yoga-based lifestyle interventions show promise in enhancing MTHFR gene expression and mitigating oxidative stress.
  • MTHFR polymorphisms are independently associated with pediatric diseases and male infertility.
  • Yoga may be a beneficial complementary approach for individuals with MTHFR deficiency and their families.