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Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging
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Novel Optofluidic Imaging System Integrated with Tunable Microlens Arrays.

Ya Zhong1,2,3, Haibo Yu1,2, Yangdong Wen4

  • 1State Key Laboratory of Robotics, Chinese Academy of Sciences, Shenyang Institute of Automation, Shenyang110016, China.

ACS Applied Materials & Interfaces
|January 19, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel method for fabricating tunable microlens arrays (MLAs) within microfluidic chips using electrohydrodynamic jet printing. This technique enables precise control over light for advanced imaging in lab-on-a-chip systems.

Keywords:
E-jet printingcell imagingin situ fabricationmicrofluidics chipoptofluidic tunable microlens array

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Area of Science:

  • Optofluidics
  • Microfluidics
  • Optical Engineering

Background:

  • Optofluidic tunable microlens arrays (MLAs) offer light manipulation capabilities for lab-on-a-chip systems.
  • Integrating 3D MLAs into narrow microfluidic channels remains a significant fabrication challenge.
  • Limited research exists on variable focal length imaging using optofluidic 3D MLAs.

Purpose of the Study:

  • To propose and demonstrate a novel method for fabricating optofluidic tunable MLAs within microfluidic channels.
  • To overcome the limitations of integrating 3D MLAs into narrow microfluidic systems.
  • To enable variable focal length imaging for microfluidic applications.

Main Methods:

  • Fabrication of MLAs in polydimethylsiloxane (PDMS)-based microchannels using electrohydrodynamic jet (E-jet) printing.
  • Creation of MLAs with diameters ranging from 15 to 80 μm within 200 and 300 μm wide microfluidic channels.
  • Utilizing solutions with different refractive indices for reversible modulation of microlens properties.

Main Results:

  • Successful fabrication of optofluidic tunable MLAs using E-jet printing.
  • Demonstration of reversible modulation properties by alternating solutions with varying refractive indices.
  • Achieved threefold tunability in focal length, enabling an imaging depth of approximately 450 μm.

Conclusions:

  • The proposed E-jet printing method effectively fabricates optofluidic tunable MLAs in microfluidic channels.
  • The developed optofluidic chip demonstrates significant potential for cell counting and imaging applications.
  • This technology facilitates in-situ observation of microspheres and cells within microfluidic systems.