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Assembled Bisphenol A with cyclic oligosaccharide as the controlled release complex to reduce risky effects
Modhusudan Mondal1, Shatarupa Basak1, Salim Ali1
1Department of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Environmental Science and Pollution Research International
|January 19, 2023
Summary
This study created a Bisphenol A (BPA) formulation using beta-cyclodextrin (β-CD) to reduce its toxicity and enhance antibacterial properties. The new formulation shows improved efficacy and controlled release, making BPA safer for therapeutic applications.
Area of Science:
- Environmental Chemistry
- Materials Science
- Biotechnology
Background:
- Bisphenol A (BPA) is a non-biodegradable pollutant with significant health concerns.
- Improving BPA's bioavailability and reducing its toxicity are critical for safer applications.
- Inclusion complexation offers a promising strategy for modifying pollutant properties.
Purpose of the Study:
- To develop an inclusion complex (IC) of beta-cyclodextrin (β-CD) with Bisphenol A (BPA).
- To investigate the impact of β-CD encapsulation on BPA's solubility, antioxidant, antibacterial, toxicity, and thermal stability.
- To explore BPA-IC's potential for controlled release and therapeutic applications.
Main Methods:
- Formation of β-CD-BPA inclusion complex.
- Characterization using UV-Vis, NMR, FTIR, XRD, TGA, and DSC.
- In silico molecular modeling for toxicity assessment.
- In vitro antibacterial activity testing.
Main Results:
- Spectroscopic and thermal analyses confirmed the formation and stability of the β-CD-BPA inclusion complex.
- Encapsulation significantly enhanced BPA's thermal stability.
- The inclusion complex demonstrated increased antibacterial activity compared to pure BPA.
- In silico studies indicated a substantial reduction in BPA's toxicity.
Conclusions:
- Beta-cyclodextrin encapsulation effectively improves Bisphenol A's properties, reducing toxicity and enhancing antibacterial efficacy.
- The developed BPA-IC formulation offers potential for controlled release and therapeutic use.
- This approach facilitates safer application of BPA by mitigating its hazardous effects and boosting efficacy.
