Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy and safety of multiple treatments for small hepatocellular carcinoma: an updated systematic review and component network meta analysis.

EClinicalMedicine·2026

Same author

Flavor and quality evolution during storage of fermented noni juice: Integrated insights from E--sensory evaluation, HS-SPME-GC-MS and LC-MS/MS.

Food chemistry·2026

Same author

Extraction, structural characterization, and immunomodulatory activity of a high-molecular-weight polysaccharide from cultured ophiocordyceps.

Carbohydrate research·2026

Same author

BASP1 promotes breast cancer progression and shapes an immunosuppressive microenvironment by recruiting MDSCs and suppressing T cell function.

Human cell·2026

Same author

International Consensus on Severe Lung Cancer-The Second Edition.

Translational lung cancer research·2026

Same author

Analysis of Changes in Taste Characteristics of Coffee at Different Primary Processing Methods Using E-Tongue, Untargeted Metabolomics and WGCNA.

Foods (Basel, Switzerland)·2026

Same journal

How important is fiber in the Crohn's disease story?

Gastroenterology·2026

Same journal

Reply to "Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy".

Gastroenterology·2026

Same journal

Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy.

Gastroenterology·2026

Same journal

A High-Risk Impaction: To Scope or to Stent First?

Gastroenterology·2026

Same journal

Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis.

Gastroenterology·2026

Same journal

Reply.

Gastroenterology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 13, 2025

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis

Published on: January 21, 2020

Injectable, Drug-Eluting Nanocrystals Prevent Fibrosis and Stricture Formation In Vivo.

Ling Li¹, Rachel L Shapiro², Min Kyung Joo³

¹Division of Gastroenterology and Hepatology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland.

Gastroenterology

|January 19, 2023

Summary

This summary is machine-generated.

A novel drug delivery system using sulconazole nanocrystals effectively prevents tissue fibrosis and stricture formation in preclinical models. This localized, sustained-release treatment shows promise for gastrointestinal conditions.

Keywords:

Fibrosis Nanocrystal Stricture Sulconazole Therapies

More Related Videos

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Related Experiment Videos

Last Updated: Aug 13, 2025

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis

Published on: January 21, 2020

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Biomedical Engineering
Pharmacology
Gastroenterology

Background:

Tissue fibrosis involves excessive extracellular matrix deposition, leading to gastrointestinal strictures.
Current treatments for gastrointestinal fibrosis are limited, necessitating novel therapeutic strategies.
Developing localized, sustained-release antifibrotic drugs is crucial for effective stricture management.

Purpose of the Study:

To identify and develop a small molecule drug with potent antifibrotic effects for localized, sustained delivery.
To evaluate the efficacy of the antifibrotic drug in preventing fibrosis and stricture formation in relevant animal models.

Main Methods:

High-throughput screening identified small molecules with antifibrotic properties.
An identified antifibrotic molecule was formulated into nanocrystals for sustained release.
Antifibrotic potential was assessed in three distinct animal models of fibrosis, including a swine model of bowel stricture.

Main Results:

Sulconazole, an FDA-approved antifungal drug, demonstrated significant antifibrotic properties.
Sulconazole nanocrystals achieved sustained release and showed superior or equivalent fibrosis prevention in mouse models compared to less frequent dosing.
A single injection of sulconazole nanocrystals successfully prevented stricture formation in a swine model.

Conclusions:

Sulconazole nanocrystals represent a promising therapeutic approach for preventing tissue fibrosis and strictures.
The localized, sustained-release formulation enhances drug efficacy and potentially reduces systemic side effects.
These findings provide a strong foundation for clinical studies investigating antifibrotic treatments for fibrotic diseases.