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Reversal of Peripheral Iris Depigmentation Associated with Vogt-Koyanagi-Harada Disease
Mohannad F Tobaigy1, Abdulrahman F AlBloushi1, Hassan A Al-Dhibi2,3
1Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabai.
Objective:
To describe the reversal of peripheral iris depigmentation associated with Vogt-Koyanagi-Harada (VKH) disease.
Methods:
A retrospective report of two cases.
Results:
Both patients were diagnosed with a chronic recurrent VKH disease and developed bilateral peripheral iris depigmentation (BPID). The first patient is an 8-year-old girl who was treated with systemic corticosteroids, methotrexate and adjuvant rituximab infusions that induced complete remission of uveitis and reversal of peripheral iris depigmentation at the last follow-up. The second was a 6-year-old who was treated with topical and systemic corticosteroids and oral methotrexate that induced complete remission of uveitis and reversal of peripheral iris depigmentation at the last follow-up.
Conclusions:
Adequate control of uveitis associated with chronic recurrent VKH disease with appropriate immunomodulatory agents and perhaps adjuvant rituximab can reverse BPID and improve the outcomes.
