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Updated: Aug 13, 2025

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors
Saak V Ovsepian1, Stephen G Waxman2,3,4
1School of Science, Faculty of Engineering and Science, University of Greenwich London, Chatham Maritime, UK. s.v.ovsepian@gre.ac.uk.
Abstract:
With sweeping advances in precision delivery systems and manipulation of the genomes and transcriptomes of various cell types, medical biotechnology offers unprecedented selectivity for and control of a wide variety of biological processes, forging new opportunities for therapeutic interventions. This perspective summarizes state-of-the-art gene therapies enabled by recent innovations, with an emphasis on the expanding universe of molecular targets that govern the activity and function of primary sensory neurons and which might be exploited to effectively treat chronic pain.
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