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Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective
Feiyang Shen1,2, Yan Fang1,2, Yijia Wu1,2
1Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Journal of Nanobiotechnology
|January 19, 2023
Summary
Metal ions impact cancer cell fate and immunity, making them valuable in antitumor therapy. Nanomedicine enhances metal ion delivery for improved cancer immunotherapy and treatment.
Area of Science:
- Oncology
- Immunology
- Nanomedicine
- Biochemistry
Background:
- Metal ions play a critical role in regulating tumor microenvironment and immune responses.
- Metal ions are utilized in antitumor therapy as immune modulators due to their influence on cancer cell fate and immunity.
- Traditional metal ion therapies face challenges like low target selectivity and systemic toxicity.
Purpose of the Study:
- To explore the physiopathology of metal ions in tumorigenesis.
- To discuss advancements in nanometallic materials for antitumor immunotherapeutics.
- To provide insights into metal ion-based nanomedicine for cancer immunotherapy.
Main Methods:
- Review of existing literature on metal ions, nanomedicine, and cancer immunotherapy.
- Analysis of the role of metal ions in cancer cell signaling and immune modulation.
- Discussion of nanometallic material applications in enhancing therapeutic efficacy.
Main Results:
- Nanomedicine offers precise delivery and responsive release, overcoming limitations of conventional metal ion therapies.
- Immunotherapy combined with nanometallic materials demonstrates significantly enhanced therapeutic efficacy.
- Metal ion-based nanomedicine shows promise in cancer therapy and prophylaxis.
Conclusions:
- Metal ion-based nanomedicine represents a significant advancement in cancer treatment and prevention.
- This approach provides novel strategies for basic immunology research and clinical applications.
- Further research into metal ions combined with nanomedicine is crucial for optimizing cancer immunotherapy.
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