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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Targeting ferroptosis in cardio-metabolic-diseases: Mechanisms and therapeutic prospects

Jia-Bao Zhang1, Jie Tong2, Di-Yang Sun1,3

  • 1Department of Pharmacology, College of Pharmacy, Naval Medical University/Second Military Medical University, Shanghai, China.

Medicinal Research Reviews
|January 20, 2023
PubMed

Insights

Ferroptosis, a regulated cell death, is increasingly linked to cardio-metabolic diseases. Understanding ferroptosis mechanisms offers new therapeutic targets for these widespread conditions.

Area of Science:

  • Biomedical science
  • Cellular biology
  • Pathophysiology

Background:

  • Cardio-metabolic diseases are a major global health burden.
  • Ferroptosis is a distinct form of regulated cell death involving iron dysregulation.
  • Emerging evidence implicates ferroptosis in cardio-metabolic disease pathogenesis.

Purpose of the Study:

  • To review ferroptosis mechanisms in cardio-metabolic diseases.
  • To elucidate the roles of ferroptosis in disease progression.
  • To identify therapeutic targets within the ferroptosis pathway.

Main Methods:

  • Comprehensive literature review.
  • Analysis of molecular mechanisms of ferroptosis.
  • Examination of ferroptosis signaling pathways.

Main Results:

  • Ferroptosis involves iron metabolism, mitochondrial dysfunction, and lipid peroxidation.
  • Ferroptosis significantly contributes to cardio-metabolic disease development.
  • Specific molecular targets within ferroptosis pathways have been identified.

Conclusions:

  • Ferroptosis plays a critical role in cardio-metabolic diseases.
  • Targeting ferroptosis presents novel therapeutic strategies.
  • Further research into ferroptosis mechanisms can advance treatment for cardio-metabolic conditions.

Keywords:
cardio-metabolic-diseasesferroptosislipid peroxidepotential druggable moleculestherapeutic target

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