Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Aug 13, 2025

Graphene Coatings for Biomedical Implants

Graphene Coatings for Biomedical Implants

Published on: March 1, 2013

Bio-inspired hemocompatible surface modifications for biomedical applications.

Megan Douglass¹, Mark Garren¹, Ryan Devine¹

¹School of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, USA.

Progress in Materials Science

|January 20, 2023

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Localized Nitric Oxide Release from a Ciprofloxacin Hybrid Conjugate Enables Potent Disruption of Gram-Positive and Gram-Negative Biofilms.

ACS applied bio materials·2026

Same author

Reactive Multifunctional Ink for Hydrogel Fabrication and Cell-Laden 3D Printing via Incorporation of Strontium-Doped Bioactive Glass.

ACS applied bio materials·2026

Same author

Development of drug-loaded MnO<sub>2</sub> nanoflowers on nitric oxide-releasing polymer platforms for antimicrobial and antifungal applications.

Journal of colloid and interface science·2026

Same author

Sustained nitric oxide-releasing aliphatic lubricants: Infusion in polymers for enhanced slippery and antibacterial efficacy.

Biomaterials advances·2026

Same author

Exploring the Versatility of Multifunctional Additives for PMMA-Based Bone Cements to Improve Clinical Performance: An Update.

ACS applied bio materials·2026

Same author

Engineering a dual-action nitric oxide and propolis releasing polymeric matrix for extended antimicrobial efficacy.

Journal of materials chemistry. B·2026

Biomimicry offers a promising approach to create hemocompatible medical device surfaces, reducing the need for systemic anticoagulants and their associated risks like bleeding and heparin-induced thrombocytopenia (HIT). This review explores innovative surface modifications inspired by nature.

Area of Science:

Biomaterials Science
Biomedical Engineering
Surface Chemistry

Background:

Blood-contacting medical devices trigger adverse biochemical reactions, leading to complications like thrombosis, inflammation, and device failure.
Current anticoagulant therapies (e.g., heparin) pose risks including bleeding and heparin-induced thrombocytopenia (HIT), a significant cause of drug-related deaths.
Minimizing risks from blood-contacting devices is critical due to their increasing use in patient care.

Purpose of the Study:

To review bio-inspired surface modifications for enhancing hemocompatibility of medical devices.
To discuss the limitations of current biomimetic surface strategies.
To explore future research directions in developing fully hemocompatible surfaces.

Main Methods:

Keywords:

Biomaterials Biomimetic Hemocompatible Medical devices

More Related Videos

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Published on: March 5, 2020

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Related Experiment Videos

Last Updated: Aug 13, 2025

Graphene Coatings for Biomedical Implants

Graphene Coatings for Biomedical Implants

Published on: March 1, 2013

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Published on: March 5, 2020

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Literature review of biomimetic approaches for medical device surface modification.

Analysis of existing studies on hemocompatibility enhancement through bio-inspired designs.

Discussion of clinical relevance and limitations of reviewed methods.

Main Results:

Bio-inspired surface modifications show potential for improving hemocompatibility, reducing thrombus formation.
Various biomimetic strategies exist, each with specific advantages and drawbacks.
Systemic anticoagulation carries significant risks, highlighting the need for alternative solutions.

Conclusions:

Biomimicry offers a pathway to develop intrinsically hemocompatible medical device surfaces.
Further research is needed to overcome limitations and translate biomimetic strategies into clinical practice.
Developing advanced hemocompatible surfaces is key to improving patient safety and device efficacy.