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Related Concept Videos

Green Algae01:21

Green Algae

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Green algae, also referred to as chlorophytes, are different from red algae in having the chloroplasts containing chlorophylls a and b, which give them their distinct green hue. However, they lack phycobiliproteins, preventing them from developing the red or blue-green pigmentation seen in red algae. In terms of photosynthetic pigment composition, green algae closely resemble plants and share a close evolutionary relationship with them. Taxonomically Green algae belong to Phylum Chlorophyta in...
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Red Algae01:23

Red Algae

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Red algae, also known as rhodophytes, are primarily found in marine environments, though some species inhabit freshwater and terrestrial ecosystems. These organisms exist in both unicellular and multicellular forms, with some multicellular varieties reaching macroscopic sizes.As phototrophic organisms, red algae contain chlorophyll a; however, their chloroplasts lack chlorophyll b. Instead, they possess phycobiliproteins, which serve as major light-harvesting pigments, similar to those found in...
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The group Stramenopiles include some phototrophic microorganisms. Members of this group possess flagella covered in numerous short, hairlike extensions, a feature that inspired the group's name, derived from the Latin words for "straw" and "hair." Some of the main categories of Stramenopiles include diatoms, golden algae, and brown algae.Diatoms are unicellular, photosynthetic eukaryotes, with over 200 known genera. They play a key role in the planktonic communities of both marine and...
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Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
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Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
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Green microalgae as a potential source of trypanocide compounds.

José Noé da Silva Júnior1, Ana Carla da Silva2, Kamila Kássia Dos Santos Oliveira

  • 1Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil.

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|January 20, 2023
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Summary

Microalgae extracts show potential as natural treatments for Chagas disease. Aqueous extracts of Chlorella vulgaris and Tetradesmus obliquus demonstrated trypanocidal activity against Trypanosoma cruzi, with C. vulgaris showing no cytotoxicity.

Keywords:
Microalgaecytotoxicitytrypanocidal activity

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Area of Science:

  • Pharmacology
  • Parasitology
  • Biotechnology

Background:

  • Chagas disease therapy is limited, necessitating novel therapeutic strategies.
  • Microalgae are a source of bioactive compounds with potential pharmaceutical applications, including antiparasitic effects.
  • Exploring natural products for drug discovery is crucial for addressing unmet medical needs.

Purpose of the Study:

  • To evaluate the trypanocidal activity of aqueous extracts from Tetradesmus obliquus and Chlorella vulgaris against Trypanosoma cruzi.
  • To assess the cytotoxic effects of these microalgal extracts on Vero cells.
  • To identify potential natural antichagasic drug candidates from microalgae.

Main Methods:

  • Preparation of aqueous extracts from T. obliquus and C. vulgaris.
  • In vitro evaluation of trypanocidal activity against trypomastigote forms of T. cruzi.
  • Cytotoxicity assays using Vero cells to determine selectivity.

Main Results:

  • Both C. vulgaris and T. obliquus extracts exhibited significant trypanocidal activity (IC50 = 32.9 µg/mL and 36.4 µg/mL, respectively).
  • C. vulgaris extract demonstrated no cytotoxicity in Vero cells (CC50 > 600 µg/mL).
  • C. vulgaris extract showed a high selectivity index (SI > 18) against T. cruzi trypomastigotes.

Conclusions:

  • Aqueous extracts of C. vulgaris and T. obliquus possess trypanocidal properties.
  • C. vulgaris extract is a promising candidate for developing natural antichagasic drugs due to its efficacy and low toxicity.
  • Microalgae represent a viable source for novel antiparasitic drug discovery.