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Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs
V Witzemann1, B Barg, Y Nishikawa
1Abteilung Neurochemie, Max-Planck-Institut für biophysikalishe Chemie, Göttingen, FRG.
FEBS Letters
|October 19, 1987
Abstract:
The contents of the mRNAs encoding the gamma- and epsilon-subunits of the nicotinic acetylcholine receptor as well as the single-channel properties of the receptor have been assessed in innervated, denervated and reinnervated rat muscle. The changes in abundance of the gamma- and epsilon-subunit mRNAs correlate with the changes in relative density of two classes of acetylcholine receptor channels. The results support the view that a switch in the relative abundance of the gamma- and epsilon-subunit mRNAs is a major mechanism in regulating the properties of acetylcholine receptor channels in muscle.