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Down-regulation of phorbol diester binding to NG115-401L neuronal cells is dependent on structure, concentration and
R R Mattingly1, M L Dreher, M R Hanley
1MRC Molecular Neurobiology Unit, University of Cambridge Medical School, England.
FEBS Letters
|October 19, 1987
Abstract:
The down-regulation of [3H]PDBu binding to a neural cell line, NG115-401L, has been examined in response to two biologically active phorbol diesters, PDBu and PMA. Chronic treatment with PDBu or PMA causes a concentration- and time-dependent loss of specific [3H]PDBu binding. The action of PMA is biphasic with respect to both concentration and time dependence.